methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Base Information

Chemical Name:methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate
CAS No.:1562195-54-3
Molecular Formula:C₂₉H₂₃ClF₅N₃O₅
Molecular Weight:623.964
Hs Code.:

Synonyms:methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

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Chemical Property of methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

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Technology Process of methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

There total 8 articles about methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.7%

: 1084953-16-1
methyl 5-fluoro-2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1562195-50-9
(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

: 1562195-54-3
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 885520-23-0
6-bromo-4-fluoro-1H-indazole

: 1562195-54-3
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr

2: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

5: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 40 °C

6: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; sodium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; 6: |Suzuki Coupling;

Reference yield:

: 1227912-19-7
6-bromo-4-fluoro-1H-indazol-3-amine

: 1562195-54-3
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: hypophosphorous acid; isopentyl nitrite / ethanol / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr

3: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

4: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

6: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / 40 °C

7: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 16 h / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; iodine; hypophosphorous acid; sodium carbonate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 7: |Suzuki Coupling;