3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

Base Information

Chemical Name:3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea
CAS No.:1022973-37-0
Molecular Formula:C₂₅H₃₆ClN₇O
Molecular Weight:486.06
Hs Code.:

Synonyms:3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

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Chemical Property of 3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

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Technology Process of 3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

There total 5 articles about 3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259274-55-9
C₂₂H₃₁ClN₆

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1022973-37-0
3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

Guidance literature:: With triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; Inert atmosphere; Sonication;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1245830-90-3
(1R,2R)-N-(2,5-dichloro-pyrimidin-4-yl)cyclohexane-1,2-diamine

: 1022973-37-0
3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

2: hydrogenchloride / 1,4-dioxane; ethyl methyl ether / 120 °C

3: potassium carbonate / methanol / 156 h / 45 °C

4: triethylamine / 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide / Inert atmosphere; Sonication

With hydrogenchloride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethyl methyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.040

Reference yield:

: 1022973-35-8
N-[(1R,2R)-2-(2,5-dichloropyrimidin-4-ylamino)cyclohexyl]-2,2,2-trifluoroacetamide

: 1022973-37-0
3-{(1R,2R)-2-[5-chloro-2-(3-ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino)pyrimidin-4-ylamino]cyclohexyl}-1,1-dimethylurea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; ethyl methyl ether / 120 °C

2: potassium carbonate / methanol / 156 h / 45 °C

3: triethylamine / 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide / Inert atmosphere; Sonication

With hydrogenchloride; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; ethyl methyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.040