4-(4-Aminophenyl)piperazin-2-one

Base Information

• Chemical Name: 4-(4-Aminophenyl)piperazin-2-one
• CAS No.: 223786-04-7
• Molecular Formula: C10H13 N3 O
• Molecular Weight: 191.233
• Hs Code.: 2933599090
• European Community (EC) Number: 847-810-8
• DSSTox Substance ID: DTXSID00588292
• Wikidata: Q82480874
• Mol file: 223786-04-7.mol

Synonyms:223786-04-7;4-(4-Aminophenyl)-2-piperazinone;4-(4-aminophenyl)piperazin-2-one;Piperazinone, 4-(4-aminophenyl)- (9CI);MFCD09047703;Piperazinone, 4-(4-aminophenyl)-;F2158-0211;SCHEMBL3125646;DTXSID00588292;AKOS000131556;MCULE-8582174098;AS-31735;SY015752;DB-024175;CS-0449757;EN300-37211;Z239126422

Chemical Property of 4-(4-Aminophenyl)piperazin-2-one

Chemical Property:

• PSA: 58.36000
• LogP: 1.18000
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 191.105862047
• Heavy Atom Count: 14
• Complexity: 211

Purity/Quality:

97% ^*data from raw suppliers

4-(4-Aminophenyl)-2-piperazinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CC(=O)N1)C2=CC=C(C=C2)N

Technology Process of 4-(4-Aminophenyl)piperazin-2-one

There total 2 articles about 4-(4-Aminophenyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(4-nitro-phenyl)-piperazin-2-one (223785-99-7) → 4-(4-amino-phenyl)-piperazin-2-one (223786-04-7)

Guidance literature:

Reference yield: 89.0%

→ 4-(4-amino-phenyl)-piperazin-2-one (223786-04-7)

Guidance literature:

Reference yield: 65.5%

4-(4-amino-phenyl)-piperazin-2-one (223786-04-7) + C13H18N6 + 1,1'-carbonyldiimidazole (530-62-1) → N-(4-(3-oxopiperazin-1-yl)phenyl)-4-(6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)piperazine-1-carboxamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

upstream raw materials:

4-(4-nitro-phenyl)-piperazin-2-one

Downstream raw materials:

4-phenylpiperazin-2-one