(E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

Base Information

Chemical Name:(E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol
CAS No.:1616845-70-5
Molecular Formula:C₁₈H₂₅BrO₃
Molecular Weight:369.299
Hs Code.:

Synonyms:(E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

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Chemical Property of (E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

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Technology Process of (E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

There total 4 articles about (E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1616845-69-2
(E)-ethyl 5-(2-bromophenyl)-3-((tetrahydro-2H-pyran-2-yloxy)methyl)pent-4-enoate

: 1616845-70-5
(E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c4ob00305e

Reference yield:

: 1616845-67-0
1-(2-bromophenyl)-5-(tetrahydro-2H-pyran-2-yloxy)pent-2-yn-1-ol

: 1616845-70-5
(E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2: propionic acid / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 20 - 140 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; propionic acid; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1039/c4ob00305e

Reference yield:

: 40365-61-5
2-(but-3-yn-1-yloxy)tetrahydropyran

: 1616845-70-5
(E)-5-(2-bromophenyl)-3-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)pent-4-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: ethyl bromide; magnesium / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3: propionic acid / 5,5-dimethyl-1,3-cyclohexadiene / 24 h / 20 - 140 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ethyl bromide; magnesium; propionic acid; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene;
DOI:10.1039/c4ob00305e