methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate

Base Information

• Chemical Name: methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate
• CAS No.: 1329996-13-5
• Molecular Formula: C₁₂H₁₃NO₅
• Molecular Weight: 251.239
• Mol file: 1329996-13-5.mol

Synonyms:methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate

Chemical Property of methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate

There total 1 articles about methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester (94790-24-6) → methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate (1329996-13-5)

Guidance literature:

With dipotassium peroxodisulfate; copper(II) sulfate; In water; acetonitrile; at 70 ℃; for 3h; diastereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0030-1260561

Reference yield: 91.0%

methyl (4R,5S)-5-[4-methoxyphenyl]-1,3-oxazolidin-2-one-4-carboxylate (1329996-13-5) → (4S,5S)-(-)-4-hydroxymethyl-5-(4-methoxyphenyl)-oxazolidin-2-one

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃;

DOI:10.1055/s-0030-1260561

upstream raw materials:

(2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester