(S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester

Base Information

• Chemical Name: (S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester
• CAS No.: 501030-49-5
• Molecular Formula: C₂₆H₂₇N₃O₃
• Molecular Weight: 429.519

Synonyms:(S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester

Chemical Property of (S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester

Chemical Property:

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Technology Process of (S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester

There total 2 articles about (S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(S)-2-pyrrol-1-yl-3-(4-formyl-phenyl)propionic acid methyl ester (501031-54-5) + (5-methyl-2-phenyl-oxazol-4-ylmethyl)-carbamic acid tert-butyl ester (501031-53-4) → (S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester (501030-49-5)

Guidance literature:

With NaBH(OAc)3; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; In dichloromethane; chloroform; 1,2-dichloro-ethane;

Reference yield: 66.0%

(S)-2-pyrrol-1-yl-3-(4-formyl-phenyl)propionic acid methyl ester (501031-54-5) + 1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)methanamine (132451-28-6) → (S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester (501030-49-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; triethylamine; In 1,2-dichloro-ethane; at 20 ℃; for 23h;

DOI:10.1016/j.bmc.2008.03.043

Reference yield: 100.0%

(S)-3-(4-{[(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester (501030-49-5) + acetic anhydride (108-24-7) → (S)-3-(4-{[acetyl-(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester (501030-50-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2008.03.043

upstream raw materials:

(S)-2-pyrrol-1-yl-3-(4-formyl-phenyl)propionic acid methyl ester

(5-methyl-2-phenyl-oxazol-4-ylmethyl)-carbamic acid tert-butyl ester

1-(5-methyl-2-phenyl-1,3-oxazol-4-yl)methanamine

Downstream raw materials:

(S)-3-(4-{[(5-Methyl-2-phenyl-oxazol-4-ylmethyl)-amino]-methyl}-phenyl)-2-pyrrol-1-yl-propionic acid

(S)-3-(4-{[Methyl-(5-methyl-2-phenyl-oxazol-4-ylmethyl)-amino]-methyl}-phenyl)-2-pyrrol-1-yl-propionic acid methyl ester

(S)-3-(4-{[acetyl-(5-methyl-2-phenyl-oxazol-4-ylmethyl)amino]methyl}phenyl)-2-pyrrol-1-yl-propionic acid methyl ester

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