1-[6-methyl-4-(methylsulfanyl)-1-phenyl-2-thioxo-1,2-dihydro-3-pyridinyl]ethanone

Base Information

• Chemical Name: 1-[6-methyl-4-(methylsulfanyl)-1-phenyl-2-thioxo-1,2-dihydro-3-pyridinyl]ethanone
• CAS No.: 90097-27-1
• Molecular Formula: C₁₅H₁₅NOS₂
• Molecular Weight: 289.422
• Mol file: 90097-27-1.mol

Synonyms:1-(6-Methyl-4-methylsulfanyl-1-phenyl-2-thioxo-1,2-dihydro-pyridin-3-yl)-ethanone

Chemical Property of 1-[6-methyl-4-(methylsulfanyl)-1-phenyl-2-thioxo-1,2-dihydro-3-pyridinyl]ethanone

Chemical Property:

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Technology Process of 1-[6-methyl-4-(methylsulfanyl)-1-phenyl-2-thioxo-1,2-dihydro-3-pyridinyl]ethanone

There total 2 articles about 1-[6-methyl-4-(methylsulfanyl)-1-phenyl-2-thioxo-1,2-dihydro-3-pyridinyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dimethyl-4-(methylthiio)pyrylium iodide (6276-12-6) → 1-(6-Methyl-4-methylsulfanyl-1-phenyl-2-thioxo-1,2-dihydro-pyridin-3-yl)-ethanone (90097-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / BaCO₃ / H₂O / 0.08 h / Heating

2: 1.) NaOCH₃ / 1.) ether, methanol, 2.) dimethyl sulfoxide, 40 deg C, 1 h

With sodium methylate; barium carbonate; In water;

DOI:10.1055/s-1983-30612

Reference yield:

(Z)-4-Methylsulfanyl-hept-3-ene-2,6-dione (90097-35-1) + phenyl isothiocyanate (103-72-0) → 1-(6-Methyl-4-methylsulfanyl-1-phenyl-2-thioxo-1,2-dihydro-pyridin-3-yl)-ethanone (90097-27-1)

Guidance literature:

With sodium methylate; Yield given. Multistep reaction; 1.) ether, methanol, 2.) dimethyl sulfoxide, 40 deg C, 1 h;

DOI:10.1055/s-1983-30612

Reference yield: 93.0%

1-(6-Methyl-4-methylsulfanyl-1-phenyl-2-thioxo-1,2-dihydro-pyridin-3-yl)-ethanone (90097-27-1) + methyl iodide (74-88-4) → 3-Acetyl-6-methyl-2,4-bis-methylsulfanyl-1-phenyl-pyridinium; iodide (111149-12-3)

Guidance literature:

In acetonitrile; for 1h; Heating;

DOI:10.1055/s-1987-27927

upstream raw materials:

(Z)-4-Methylsulfanyl-hept-3-ene-2,6-dione

phenyl isothiocyanate

2,6-dimethyl-4-(methylthiio)pyrylium iodide

Downstream raw materials:

(E)-1-(6-Methyl-4-methylsulfanyl-1-phenyl-2-thioxo-1,2-dihydro-pyridin-3-yl)-3-phenyl-propenone

3-Acetyl-6-methyl-2,4-bis-methylsulfanyl-1-phenyl-pyridinium; iodide

2-(3-Acetyl-6-methyl-2-methylsulfanyl-1-phenyl-1H-pyridin-4-ylidene)-malononitrile

3-Hydroxy-1,6-dimethyl-8-oxo-7-phenyl-7,8-dihydro-[2,7]naphthyridine-4-carbonitrile

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