(2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone
• CAS No.: 1224455-55-3
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.301
• Mol file: 1224455-55-3.mol

Synonyms:(2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone

Chemical Property of (2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone

There total 2 articles about (2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

isochroman-1-one (4702-34-5) + 4-methoxyphenyl magnesium bromide (13139-86-1) → (2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone (1224455-55-3)

Guidance literature:

isochroman-1-one; 4-methoxyphenyl magnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h; Inert atmosphere;

In tetrahydrofuran; diethyl ether; Acidic conditions;

DOI:10.1016/j.tet.2010.02.087

Reference yield:

3,4-dihydro-1-(4-methoxyphenyl)-1H-2-benzopyran (2292-60-6) → (2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone (1224455-55-3)

Guidance literature:

3,4-dihydro-1-(4-methoxyphenyl)-1H-2-benzopyran; With triphenylmethyl perchlorate; In dichloromethane; at 20 ℃; for 0.5h;

With indole; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.tetlet.2019.03.032

Reference yield: 85.0%

(2-(2-hydroxyethyl)phenyl)(4-methoxyphenyl)methanone (1224455-55-3) + 1-Adamantanecarbonyl chloride (2094-72-6) → 2-(4-methoxybenzoyl)phenethyl adamantanoate (1224454-92-5)

Guidance literature:

With triethylamine; In dichloromethane; at 50 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2010.02.087

upstream raw materials:

isochroman-1-one

4-methoxyphenyl magnesium bromide

3,4-dihydro-1-(4-methoxyphenyl)-1H-2-benzopyran

Downstream raw materials:

2-(4-methoxybenzoyl)phenethyl adamantanoate