6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt

Base Information

• Chemical Name: 6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt
• CAS No.: 77628-11-6
• Molecular Formula: C₇H₈O₃S*C₂₁H₂₄N₂O₃S
• Molecular Weight: 556.704
• Mol file: 77628-11-6.mol

Synonyms:6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt

Chemical Property of 6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt

There total 2 articles about 6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6L-carbobenzyloxyamino-3D-carboxy-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine (21142-82-5) → 6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt (77628-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 1M hydrogen bromide / acetic acid / 30 min., then 4 h, r.t.

With hydrogen bromide; In acetic acid;

DOI:10.1139/v81-062

Reference yield:

6L-amino-3D-carboxy-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine hydrobromide salt (21142-84-7) → 6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt (77628-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / pyridine; CHCl₃; ethanol

2: 2.) DMF, 50 degC

In pyridine; ethanol; chloroform;

DOI:10.1139/v81-062

Reference yield: 96.0%

6L-amino-3D-benzhydryloxycarbonyl-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine p-toluenesulfonic acid salt (77628-11-6) → 3D-benzhydryloxycarbonyl-6L-amino-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine (77628-10-5)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate;

DOI:10.1139/v81-062

upstream raw materials:

6L-amino-3D-carboxy-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine hydrobromide salt

6L-carbobenzyloxyamino-3D-carboxy-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine

Downstream raw materials:

(3S,6R)-6-((S)-5-Benzhydryloxycarbonyl-5-tert-butoxycarbonylamino-pentanoylamino)-2,2-dimethyl-5-oxo-[1,4]thiazepane-3-carboxylic acid benzhydryl ester

(3S,6R)-6-[(S)-5-Benzhydryloxycarbonyl-5-(2-tert-butoxycarbonylamino-acetylamino)-pentanoylamino]-2,2-dimethyl-5-oxo-[1,4]thiazepane-3-carboxylic acid benzhydryl ester

3D-benzhydryloxycarbonyl-6L-amino-2,2-dimethyl-5-oxoperhydro-1,4-thiazepine

2-[(R)-2-Amino-3-(benzothiazol-2-yldisulfanyl)-propionylamino]-3-methyl-but-2-enoic acid benzhydryl ester