N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide

Base Information

• Chemical Name: N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide
• CAS No.: 1447331-34-1
• Molecular Formula: C₁₇H₁₇NO₆S
• Molecular Weight: 363.391
• Mol file: 1447331-34-1.mol

Synonyms:N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide

Chemical Property of N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide

There total 2 articles about N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C6H7NOS*H(1+) + 3,4,5-trimethoxybenzoylformic acid (88755-16-2) → N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide (1447331-34-1)

Guidance literature:

3,4,5-trimethoxybenzoylformic acid; With 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1h;

C₆H₇NOS*H⁽¹⁺⁾; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

DOI:10.1016/j.tetlet.2013.05.095

Reference yield:

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide (1447331-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: selenium(IV) oxide; pyridine

2.1: 1,1'-carbonyldiimidazole / 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

2.2: 20 °C

With pyridine; selenium(IV) oxide; 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one;

DOI:10.1016/j.tetlet.2013.05.095

Reference yield: 37.0%

N-(2-thiophen-2-yl-2-oxoethyl)-2-(3,4,5-trimethoxyphenyl)-2-oxoacetamide (1447331-34-1) → 5-thiophen-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazine-2(1H)-one (1447330-84-8)

Guidance literature:

With ammonium acetate; In acetic acid; at 160 ℃; for 0.0666667h; Sealed tube; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.05.095

upstream raw materials:

3,4,5-trimethoxybenzoylformic acid

methyl (3,4,5-trimethoxyphenyl) ketone

Downstream raw materials:

5-thiophen-2-yl-3-(3,4,5-trimethoxyphenyl)pyrazine-2(1H)-one