(E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:(E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide
CAS No.:1612774-23-8
Molecular Formula:C₂₇H₃₂N₆O₃
Molecular Weight:488.589
Hs Code.:

Synonyms:(E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

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Chemical Property of (E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

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Technology Process of (E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

There total 11 articles about (E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 149586-32-3
(2E)-4-(dimethylamino)but-2-enoic acid

: 1609467-45-9
5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide

: 1612774-23-8
(E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 330792-69-3
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

: 1612774-23-8
(E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / ethanol / 16 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 35 h / 20 - 75 °C

3: dihydrogen peroxide; water; sodium hydroxide / ethanol; dimethyl sulfoxide / 0.25 h / 60 °C

4: hydrogenchloride / ethyl acetate; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With hydrogenchloride; water; dihydrogen peroxide; caesium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1612774-23-8
(E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)piperidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / pyridine / 48 h / 20 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 35 h / 20 - 75 °C

3: dihydrogen peroxide; water; sodium hydroxide / ethanol; dimethyl sulfoxide / 0.25 h / 60 °C

4: hydrogenchloride / ethyl acetate; water / 1 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C

With pyridine; hydrogenchloride; water; dihydrogen peroxide; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In pyridine; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;