Technology Process of 6-phenyl-2,3,4,5-tetrahydrothiepine
There total 5 articles about 6-phenyl-2,3,4,5-tetrahydrothiepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ja306731u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: cerium(III) chloride / tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / -78 - 20 °C / Inert atmosphere
With
cerium(III) chloride; trifluoroacetic acid;
In
tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja306731u
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 0.08 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: water; lithium chloride / dimethyl sulfoxide / 5 h / 185 °C / Inert atmosphere
3.1: cerium(III) chloride / tetrahydrofuran; diethyl ether / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
3.3: Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / -78 - 20 °C / Inert atmosphere
With
cerium(III) chloride; water; trifluoroacetic acid; lithium chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ja306731u
