N²,N⁶-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide

Base Information

• Chemical Name: N²,N⁶-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide
• CAS No.: 158946-78-2
• Molecular Formula: C₂₅H₂₃N₃O₆
• Molecular Weight: 461.474
• Mol file: 158946-78-2.mol

Synonyms:N²,N⁶-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide

Chemical Property of N²,N⁶-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²,N⁶-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide

There total 7 articles about N²,N⁶-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Pyridine-2,6-dicarboxylic acid (499-83-2) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N2,N6-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide (158946-78-2)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.3762/bjoc.8.128

Reference yield: 87.0%

N,N'-bis[(S)-1-methoxycarbonyl-2-phenylethyl]-2,6-pyridinecarboxamide (158946-83-9) → N2,N6-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide (158946-78-2)

Guidance literature:

With water; sodium hydroxide; In methanol; at -5 - 20 ℃; for 5h;

DOI:10.5560/ZNB.2012-0116

Reference yield:

2,6-Pyridinedicarbonyl dichloride (3739-94-4) → N2,N6-bis(3-phenylpropanoic acid-2-yl)pyridine-2,6-dicarboxamide (158946-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine / dichloromethane / -15 °C

1.2: 15 h / -15 - 20 °C

2.1: sodium hydroxide; water / methanol / 5 h / -5 - 20 °C

With 4-methyl-morpholine; water; sodium hydroxide; In methanol; dichloromethane;

DOI:10.5560/ZNB.2012-0116

upstream raw materials:

2,6-Pyridinedicarbonyl dichloride

L-phenylalanine

N,N'-bis[(S)-1-methoxycarbonyl-2-phenylethyl]-2,6-pyridinecarboxamide

Pyridine-2,6-dicarboxylic acid

Downstream raw materials:

C₃₅H₄₁N₅O₈

C₄₃H₄₁N₅O₈

C₄₂H₅₃N₇O₈

C₅₀H₅₃N₇O₈