158946-83-9Relevant academic research and scientific papers
Chirality induction of π-conjugated chains through chiral complexation
Moriuchi, Toshiyuki,Shen, Xiuliang,Hirao, Toshikazu
, p. 12237 - 12246 (2006)
Chirality induction of π-conjugated polyanilines through chiral complexation with the chiral palladium(II) complexes was demonstrated to afford the chiral conjugated polymer complexes. Complexation of the emeraldine base of poly(o-toluidine) (POT) with th
Macrocyclic compound as NMR chiral solvating agent for determination of enantiomeric excess of carboxylic acids
Yang, Xiao-Feng,Ning, Rui,Xie, Li-Jun,Cui, Yu,Zhang, Yong-Ling,Zheng, Lu-Yi
, p. 987 - 989 (2013)
1HNMR studies demonstrated that chiral macrocycle 1 was a good chiral solvating agent, and was effective for the determination of the enantiomeric excess of a wide range of rac-carboxylic acids. Large nonequivalent chemical shifts (up to 0.125 ppm) can be
Chirality induction of polyaniline derivatives through chiral complexation
Shen, Xiuliang,Moriuchi, Toshiyuki,Hirao, Toshikazu
, p. 4733 - 4736 (2004)
Chirality induction of π-conjugated polyaniline derivatives was achieved by chiral complexation with chiral palladium(II) complexes. The crystal structure of the chiral conjugated complex with a model compound of the polyaniline, N,N-bis(4′-dimethylaminophenyl)-1,4- benzoquinonediimine, revealed a chiral propeller twist conformation of the π-conjugated moiety.
Design, synthesis and docking studies of novel macrocyclic pentapeptides as anticancer multi-targeted kinase inhibitors
Abo-Ghalia, Mohamed H.,Al-Omar, Mohamed A.,Amr, Abd El-Galil E.,Elsayed, Elsayed A.,Moustafa, Gaber O.,Nossier, Eman S.
, (2018/09/29)
A series of macrocyclic pyrido-pentapeptide candidates 2-6 were synthesized by using N,N-bis-[1-carboxy-2-(benzyl)]-2,6-(diaminocarbonyl)pyridine 1a,b as starting material. Structures of the newly synthesized compounds were established by IR, 1H and 13C-NMR, and MS spectral data and elemental analysis. The in-vitro cytotoxicity activity was investigated for all compounds against MCF-7 and HepG-2 cell lines and the majority of the compounds showed potent anticancer activity against the tested cell lines in comparison with the reference drugs. Out of the macrocyclic pyrido-pentapeptide based compounds, 5c showed encouraging inhibitory activity on MCF-7 and HepG-2 cell lines with IC50 values 9.41 1.25 and 7.53 1.33 M, respectively. Interestingly, 5c also demonstrated multitarget profile and excellent inhibitory activity towards VEGFR-2, CDK-2 and PDGFR? kinases. Furthermore, molecular modeling studies of the compound 5c revealed its possible binding modes into the active sites of those kinases.
Synthesis and reactions of new chiral linear and macrocyclic tetraand penta-peptide candidates
Abo-Ghalia, Mohamed H.,El-Hamid, Mohamed Abd,Zweil, Mohamed A. El-Galil,Amrc, Abd El-Galil E.,Moafi, Shimaa A.
, p. 806 - 818 (2012/11/13)
A series of linear and macrocyclic pentapeptide derivatives have been prepared via the coupling of pyridine-2,6-dicarboxylic acid (1) or pyridine-2,6-dicarbonyl dichloride (2) with appropriate amino acid methyl esters. The coupling of 1 or 2 with aminoacid methyl esters gave the corresponding pyridine dipeptide methyl esters 3, which were hydrolyzed with sodium hydroxide to the corresponding acids 4. The latter compounds 4 were coupled with other amino acid methyl esters to afford the corresponding tetrapeptide esters 5, which were hydrolyzed with sodium hydroxide to the corresponding acids 6. Cyclization of tetrapeptide acids with L-lysine methyl ester or with aliphatic diamide derivatives afforded the corresponding cyclic pentapeptide methyl ester derivatives 7 and cyclic tetrapeptide diamines 8, respectively. Finally, hydrolysis with 1 N sodium hydroxide or hydrazinolysis with hydrazine hydrate of methyl esters 7 afforded the corresponding acids 9a - e and hydrazides 10a - e, respectively.
Synthesis of new chiral macrocyclic tetraoxo polyamines containing pyridine ring and functional arms
You, Jingsong,Yu, Xiaoqi,Liu, Changlu,Xie, Rugang
, p. 2447 - 2455 (2007/10/03)
Seven new chiral macrocyclic tetraoxo polyamines containing pyridine ring and functional arms derived from L-hiStidine, L-alanine, L-leucine and L-phenylalanine, respectively, have been synthesized and characterized by MS, 1H NMR and elemental analysis.
Synthesis of new potential bis-intercalators based on chiral pyridine-2,6-dicarboxamides
Amr, Abd El-Galil,Abd El-Salam, Osama I.,Attia, Abd El-Hamid,Stibor, Ivan
, p. 288 - 298 (2007/10/03)
Potential bis-intercalating compounds N,N-dibenzylidene-N2,N2′-(pyridine-2,6-dicarbonyl)-d i(aminoacidhydrazides) 4a-4j, N,N′-substituted pyridine-2,6-bis(carbohydrazides) 5a-5d and N,N′-substituted N2N2′-bis(pyridine-2,6-dicarbonyl)di(aminoacidhydraz ides) 6a-6g, both racemic and optically active, can be easily synthesized from pyridine-2,6-bis(carbohydrazide), natural amino acids and aromatic aldehydes or anhydrides of aromatic ortho-dicarboxylic acids.
