(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

Base Information

Chemical Name:(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine
CAS No.:151223-24-4
Molecular Formula:C₂₉H₃₈N₅O₆P
Molecular Weight:583.624
Hs Code.:

Synonyms:(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

Suppliers and Price of (R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

Chemical Property:

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Technology Process of (R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

There total 1 articles about (R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138247-55-9
(R)-3-O-benzyl-2-O-<(diisopropylphosphono)methyl>-1-O-(methylsulfonyl)glycerol

: 19916-73-5
2-Amino-6-benzyloxypurine

: 151223-24-4
(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

Guidance literature:: With caesium carbonate; In acetonitrile; for 16h; Heating;
DOI:10.1021/jm00094a005

Reference yield: 81.0%

: 151223-24-4
(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

: 14470-28-1
mono-4-methoxytrityl chloride

: 151223-25-5
(S)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

Guidance literature:: With dmap; triethylamine; In N,N-dimethyl-formamide; at 40 ℃; for 20h;
DOI:10.1021/jm00071a003

Reference yield:

: 151223-24-4
(R)-6-O-benzyl-9-<3-(benzyloxy)-2-<(diisopropylphosphono)methoxy>propyl>guanine

: 151223-26-6
(S)-9-<3-hydroxy-2-<(diisopropylphosphono)methoxy>propyl>-N²-<(p-methoxyphenyl)diphenylmethyl>guanine

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / 4-(dimethylamino)pyridine, Et₃N / dimethylformamide / 20 h / 40 °C

2: 51 percent / cyclohexene / 20percent Pd(OH)2/C / ethanol / 14 h / Heating

With dmap; triethylamine; cyclohexene; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a003