5-Chloro-2-ethenylpyridine

Base Information

• Chemical Name: 5-Chloro-2-ethenylpyridine
• CAS No.: 223445-06-5
• Molecular Formula: C7H6 Cl N
• Molecular Weight: 139.584
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID40573965
• Wikidata: Q82462823
• Mol file: 223445-06-5.mol

Synonyms:5-chloro-2-ethenylpyridine;223445-06-5;5-Chloro-2-vinylpyridine;Pyridine, 5-chloro-2-ethenyl- (9CI);MFCD00081082;5-chloro-2-vinyl-pyridine;SCHEMBL266083;SCHEMBL12114796;DTXSID40573965;ZTUBASSWZGSMFJ-UHFFFAOYSA-N;YIA44506;AKOS037644628;PB42073;AS-54122;SY279523;CS-0050535;P17531;EN300-1967975

Chemical Property of 5-Chloro-2-ethenylpyridine

Chemical Property:

• PSA: 12.89000
• LogP: 2.37800
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 139.0188769
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-2-vinylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC1=NC=C(C=C1)Cl

Technology Process of 5-Chloro-2-ethenylpyridine

There total 4 articles about 5-Chloro-2-ethenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,5 dichloropyridine (16110-09-1) + potassium vinyltrifluoroborate → 5-Chloro-2-vinyl-pyridine (223445-06-5)

Guidance literature:

With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In ethanol; Heating / reflux;

Reference yield:

2,5 dichloropyridine (16110-09-1) + tri-n-butyl-vinylstannane → 5-Chloro-2-vinyl-pyridine (223445-06-5)

Guidance literature:

Pd(PPh₃)4; In ethyl acetate; toluene;

Reference yield:

2,5 dichloropyridine (16110-09-1) + tri-n-butyl(vinyl)tin (7486-35-3) → 5-Chloro-2-vinyl-pyridine (223445-06-5)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 3h; Heating / reflux;

upstream raw materials:

2,5 dichloropyridine

tri-n-butyl(vinyl)tin

Downstream raw materials:

5-chloropicolinic acid