4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

Base Information

Chemical Name:4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine
CAS No.:1345724-18-6
Molecular Formula:C₁₉H₁₇F₃N₄O
Molecular Weight:374.365
Hs Code.:

Synonyms:4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

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Chemical Property of 4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

Chemical Property:

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Technology Process of 4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

There total 4 articles about 4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1345724-24-4
dibenzyl-[4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

: 1345724-18-6
4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

Guidance literature:: With cyclohexa-1,4-diene; palladium(II) hydroxide; In ethanol; at 80 ℃; Inert atmosphere;

Reference yield:

: 1345724-19-7
4-dibenzylamino-3-trifluoromethyl-benzonitrile

: 1345724-18-6
4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 - 0 °C / Inert atmosphere

1.2: -78 - 20 °C

1.3: 110 °C / Inert atmosphere

2.1: 100 °C / Inert atmosphere

3.1: cyclohexa-1,4-diene / palladium(II) hydroxide / ethanol / 80 °C / Inert atmosphere

With cyclohexa-1,4-diene; lithium diisopropyl amide; palladium(II) hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 1345724-22-2
dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

: 1345724-18-6
4-(5-morpholin-4-yl-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 100 °C / Inert atmosphere

2: cyclohexa-1,4-diene / palladium(II) hydroxide / ethanol / 80 °C / Inert atmosphere

With cyclohexa-1,4-diene; palladium(II) hydroxide; In ethanol;