dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

Base Information

Chemical Name:dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine
CAS No.:1345724-22-2
Molecular Formula:C₂₉H₂₁ClF₃N₃
Molecular Weight:503.954
Hs Code.:

Synonyms:dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

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Chemical Property of dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

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Technology Process of dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

There total 4 articles about dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1345724-19-7
4-dibenzylamino-3-trifluoromethyl-benzonitrile

2,3-dimethoxybenzonitrile: 5653-62-3
2,3-dimethoxybenzonitrile

: 1345724-22-2
dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

Guidance literature:: 2,3-dimethoxybenzonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 2h; Inert atmosphere;

4-dibenzylamino-3-trifluoromethyl-benzonitrile; In tetrahydrofuran; at -78 - 20 ℃;

With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃; Inert atmosphere;

Reference yield: 20.0%

: 3222-56-8
2-methylnicotinic acid

: 1345724-19-7
4-dibenzylamino-3-trifluoromethyl-benzonitrile

: 1345724-22-2
dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

Guidance literature:: 2-methylnicotinic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃; for 2h; Inert atmosphere;

4-dibenzylamino-3-trifluoromethyl-benzonitrile; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃; for 18h; Inert atmosphere;

Reference yield:

: 100-39-0
benzyl bromide

: 1345724-22-2
dibenzyl-[4-(5-chloro-[1,6]naphthyridin-7-yl)-2-trifluoromethylphenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C

2.3: 110 °C / Inert atmosphere

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;