1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Base Information

Chemical Name:1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride
CAS No.:1443991-26-1
Molecular Formula:C₂₁H₁₅Cl₂N₃O₃
Molecular Weight:428.274
Hs Code.:

Synonyms:1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Suppliers and Price of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

There total 4 articles about 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1146757-92-7
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

: 1443991-26-1
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Guidance literature:: With thionyl chloride; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2013.04.075

Reference yield:

: 1443991-21-6
ethyl 4-(2,6-dimethoxyphenyl)-4-hydroxy-2-oxobut-3-enoate

: 1443991-26-1
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / ethanol / 3 h / 20 - 100 °C / Microwave irradiation

2: sodium hydroxide; water / tetrahydrofuran

3: thionyl chloride / 3 h / 20 °C

With thionyl chloride; sulfuric acid; water; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2013.04.075

Reference yield:

: 2040-04-2
2,6-dimethoxyacetophenone

: 1443991-26-1
1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carbonyl chloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium / ethanol / 6 h / 20 °C

2: sulfuric acid / ethanol / 3 h / 20 - 100 °C / Microwave irradiation

3: sodium hydroxide; water / tetrahydrofuran

4: thionyl chloride / 3 h / 20 °C

With thionyl chloride; sulfuric acid; water; sodium; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2013.04.075