1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

Base Information

• Chemical Name: 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid
• CAS No.: 1146757-92-7
• Molecular Formula: C₂₁H₁₆ClN₃O₄
• Molecular Weight: 409.829
• Mol file: 1146757-92-7.mol

Synonyms:1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

Chemical Property of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid

There total 8 articles about 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate (1443991-22-7) → 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (1146757-92-7)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmc.2013.04.075

Reference yield: 78.0%

methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate (1612148-70-5) → 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (1146757-92-7)

Guidance literature:

methyl 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate; With lithium hydroxide; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

With hydrogenchloride; In water; Inert atmosphere;

DOI:10.1021/jm5003843

Reference yield:

2,6-dimethoxyacetophenone (2040-04-2) → 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylic acid (1146757-92-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium ethanolate / ethanol / 0.42 h / 80 °C / Microwave irradiation

2: N,N-dimethyl-formamide / 3 h / 140 °C / Microwave irradiation

3: potassium hydroxide / water; tetrahydrofuran / 2 h / 120 °C / Microwave irradiation

With sodium ethanolate; potassium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 1: |Claisen Condensation;

DOI:10.1002/chem.201300696

upstream raw materials:

ethyl 1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxylate

2'-hydroxy-6'-methoxyacetophenone

2,6-dimethoxyacetophenone

(7-chloroquinolin-4-yl)-hydrazine hydrochloride

Downstream raw materials:

tert-butyl 2-[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido]adamantane-2-carboxylate

1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cycloheptanecarboxylic acid

1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylic acid

1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylic acid