(4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one

Base Information

Chemical Name:(4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one
CAS No.:500131-76-0
Molecular Formula:C₂₇H₃₇NO₃Si
Molecular Weight:451.681
Hs Code.:

Synonyms:(4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one

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Chemical Property of (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one

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Technology Process of (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one

There total 2 articles about (4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 105262-86-0
2-((tert-butyldimethylsilyl)oxy)benzyl bromide

: 500131-75-9
(4R)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one

: 500131-76-0
(4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one

Guidance literature:: (4R)-4-Phenylhexahydropyrido<2,1-c><1,4>oxazin-1-one; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

2-((tert-butyldimethylsilyl)oxy)benzyl bromide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at -78 ℃; for 3h; Further stages.;
DOI:10.1021/jo026228h

Reference yield:

: 88056-92-2
(-)-2-cyano-6-phenyloxazolopiperidine

: 500131-76-0
(4R,9aR)-9a-(2-tert-butyldimethylsiloxybenzyl)-4-phenylhexahydropyrido[2,1-c][1,4]oxazin-1(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HCl; SiO₂ / ethanol; toluene

1.2: 74 percent / Zn(BH₄)2 / diethyl ether

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 44 percent / HMPA / tetrahydrofuran / 3 h / -78 °C

With hydrogenchloride; silica gel; lithium diisopropyl amide; In tetrahydrofuran; ethanol; toluene;
DOI:10.1021/jo026228h