Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

Base Information

Chemical Name:Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide
CAS No.:1607465-20-2
Molecular Formula:C₄₆H₆₃N₁₁O₁₂S
Molecular Weight:994.139
Hs Code.:

Synonyms:Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

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Chemical Property of Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

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Technology Process of Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

There total 3 articles about Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1607465-17-7
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide

: 20866-46-0
N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine

: 1607465-20-2
Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

Guidance literature:: With dmap; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201303664

Reference yield:

: 1607465-16-6
N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

: 1607465-20-2
Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

2: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664

Reference yield:

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 1607465-20-2
Nα,Nδ-di-Boc-[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 3 h / Reflux

2: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; 2-chloro-1-methyl-pyridinium iodide; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664