N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

Base Information

Chemical Name:N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide
CAS No.:1607465-16-6
Molecular Formula:C₂₄H₃₃N₅O₆S
Molecular Weight:519.622
Hs Code.:

Synonyms:N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

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Chemical Property of N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

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Technology Process of N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

There total 1 articles about N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 104010-92-6
2,3-bis(tert-butoxycarbonyl amino)propanoic acid

: 1607465-16-6
N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 3h; Reflux;
DOI:10.1002/chem.201303664

Reference yield: 99.0%

: 1607465-16-6
N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

: 1607465-17-7
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/chem.201303664

Reference yield:

: 1607465-16-6
N,N-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2,3-diaminopropanamide

: [N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2,3-diaminopropanamide]dihistidinamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

2: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

With dmap; benzotriazol-1-ol; triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664