methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

Base Information

Chemical Name:methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate
CAS No.:1561957-82-1
Molecular Formula:C₃₁H₄₄F₃N₃O₅S
Molecular Weight:627.769
Hs Code.:

methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

Synonyms:methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

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Chemical Property of methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

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Technology Process of methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

There total 8 articles about methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 951160-35-3
methyl 4-amino-2,2-dimethylbutanoate hydrochloride

: 1561964-51-9
1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxylic acid

: 1561957-82-1
methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 30 ℃; for 1h;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561957-82-1
methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 30 °C

2.1: tetrahydrofuran / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

5.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

6.1: potassium tert-butylate; water / dimethyl sulfoxide / 1 h / 90 °C

7.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 30 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; ammonium cerium (IV) nitrate; potassium tert-butylate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1561964-36-0
ethyl 5-formyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561957-82-1
methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 0 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

4.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

5.1: potassium tert-butylate; water / dimethyl sulfoxide / 1 h / 90 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 30 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; ammonium cerium (IV) nitrate; potassium tert-butylate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;