4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Chemical Name:4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid
CAS No.:1561957-84-3
Molecular Formula:C₃₀H₄₂F₃N₃O₅S
Molecular Weight:613.742
Hs Code.:

Synonyms:4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Chemical Property of 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

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Technology Process of 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

There total 9 articles about 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1561957-82-1
methyl 4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoate

: 1561957-84-3
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In methanol; water; at 20 ℃; for 6h;

Reference yield:

: 6339-66-8
ethyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate

: 1561957-84-3
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C

1.2: 30 °C

2.1: tetrahydrofuran / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

3.2: 0 - 20 °C

4.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

5.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

6.1: potassium tert-butylate; water / dimethyl sulfoxide / 1 h / 90 °C

7.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 30 °C

8.1: lithium hydroxide monohydrate / water; methanol / 6 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; ammonium cerium (IV) nitrate; lithium hydroxide monohydrate; potassium tert-butylate; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1561964-36-0
ethyl 5-formyl-1-(4-methoxybenzyl)-4-methyl-1H-pyrrole-3-carboxylate

: 1561957-84-3
4-(1-(4-(N-(tert-butyl)sulfamoyl)-3-(trifluoromethyl)phenyl)-5-(cyclohexylmethyl)-4-methyl-1H-pyrrole-3-carboxamido)-2,2-dimethylbutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 0 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 0.25 h / 0 °C

2.2: 0 - 20 °C

3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.67 h / 20 °C

4.1: potassium phosphate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / toluene / Inert atmosphere; Reflux

5.1: potassium tert-butylate; water / dimethyl sulfoxide / 1 h / 90 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 30 °C

7.1: lithium hydroxide monohydrate / water; methanol / 6 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; ammonium cerium (IV) nitrate; lithium hydroxide monohydrate; potassium tert-butylate; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;