5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine

Base Information

• Chemical Name: 5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine
• CAS No.: 132018-92-9
• Molecular Formula: C₃₆H₄₁N₉O₁₆P₂
• Molecular Weight: 917.72
• Mol file: 132018-92-9.mol

Synonyms:5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine

Chemical Property of 5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine

There total 2 articles about 5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Cbz-L-Phe (1161-13-3) → 5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine (132018-92-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / Et₃N / acetonitrile / Ambient temperature

2: 1.) Dowex 1x8-200 ion-exchange beads (Bu₄N-form), Bu₄NOH / 1.) H₂O, 2.) DMF, RT, 2.5 h

With Dowex 1x8-200 ion-exchange beads (Bu₄N-form); tetra(n-butyl)ammonium hydroxide; triethylamine; In acetonitrile;

DOI:10.1021/ja00007a055

Reference yield:

N-(carbobenzyloxy)phenylalanine cyanomethyl ester (7663-85-6) + 5'-O-phosphoryl-2'-deoxycytidylyl-(3'->5')adenosine (127067-28-1) → 5'-phospho-2'-deoxycytidylyl(3'-5')-2'-O-adenosine (132018-91-8) + 5'-phospho-2'-deoxycytidylyl(3'-5')-3'-O-adenosine (132018-92-9)

Guidance literature:

With Dowex 1x8-200 ion-exchange beads (Bu₄N-form); tetra(n-butyl)ammonium hydroxide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) H₂O, 2.) DMF, RT, 2.5 h;

DOI:10.1021/ja00007a055

upstream raw materials:

N-(carbobenzyloxy)phenylalanine cyanomethyl ester

5'-O-phosphoryl-2'-deoxycytidylyl-(3'->5')adenosine

N-Cbz-L-Phe