5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

Base Information

Chemical Name:5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile
CAS No.:371766-31-3
Molecular Formula:C₄₄H₃₆N₄
Molecular Weight:620.797
Hs Code.:

5-[benzyl-(1-trityl-1<i>H</i>-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

Synonyms:5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

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Chemical Property of 5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

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Technology Process of 5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

There total 7 articles about 5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 100-44-7
benzyl chloride

: 565451-82-3
2'-methyl-5-[(1-trityl-1H-imidazol-4-ylmethyl)-amino]-biphenyl-2-carbonitrile

: 371766-31-3
5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0960-894X(03)00096-9

Reference yield:

: 16419-60-6
2-Methylphenylboronic acid

: 371766-31-3
5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / CsF; Pd(OAc)2; 2-(dimethylamino)-2'-dicyclohexylphosphinobiphenyl / dioxane

2: 91 percent / LiOH / tetrahydrofuran; methanol

3: DPPA; Et₃N

4: TFA / CH₂Cl₂

5: 74 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

6: 92 percent / t-BuOK / tetrahydrofuran / 0 °C

With palladium diacetate; lithium hydroxide; diphenyl-phosphinic acid; potassium tert-butylate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; cesium fluoride; trifluoroacetic acid; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00096-9

Reference yield:

: 214759-66-7
methyl 3-chloro-4-cyanobenzoate

: 371766-31-3
5-[benzyl-(1-trityl-1H-imidazol-4-ylmethyl)-amino]-2'-methyl-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / CsF; Pd(OAc)2; 2-(dimethylamino)-2'-dicyclohexylphosphinobiphenyl / dioxane

2: 91 percent / LiOH / tetrahydrofuran; methanol

3: DPPA; Et₃N

4: TFA / CH₂Cl₂

5: 74 percent / NaBH(OAc)3; AcOH / 1,2-dichloro-ethane

6: 92 percent / t-BuOK / tetrahydrofuran / 0 °C

With palladium diacetate; lithium hydroxide; diphenyl-phosphinic acid; potassium tert-butylate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; cesium fluoride; trifluoroacetic acid; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00096-9