(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Base Information

Chemical Name:(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester
CAS No.:161693-55-6
Molecular Formula:C₃₆H₄₃NO₄
Molecular Weight:553.742
Hs Code.:

Synonyms:(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Suppliers and Price of (2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

There total 11 articles about (2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 161693-54-5
(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-4-trifluoromethanesulfonyloxy-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

: 161693-55-6
(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Guidance literature:: With formic acid; tributyl-amine; Pd(PPh₃)(OAc)2;
DOI:10.1021/jo00109a006

Reference yield:

: 183312-54-1
3-benzyloxypropylmagnesium bromide

: 161693-55-6
(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / CuBr, BF₃*OEt₂ / -78 °C

2: 88 percent / NaIO₄ / OsO₄

3: 92 percent / TsOH / benzene / 52 °C

5: 86 percent / Bu₃N, HCO₂H / (Ph₃P)Pd(OAc)2

With sodium periodate; formic acid; tributyl-amine; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; copper(I) bromide; osmium(VIII) oxide; Pd(PPh₃)(OAc)2; In benzene;
DOI:10.1021/jo00109a006

Reference yield:

: 1885-14-9
phenyl chloroformate

: 161693-55-6
(2R,5R,8aS)-2,5-Bis-(3-benzyloxy-propyl)-3,5,6,7,8,8a-hexahydro-2H-quinoline-1-carboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / n-BuLi

2: 79 percent / CuBr, BF₃*OEt₂ / -78 °C

3: 88 percent / NaIO₄ / OsO₄

4: 92 percent / TsOH / benzene / 52 °C

6: 86 percent / Bu₃N, HCO₂H / (Ph₃P)Pd(OAc)2

With sodium periodate; n-butyllithium; formic acid; tributyl-amine; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; copper(I) bromide; osmium(VIII) oxide; Pd(PPh₃)(OAc)2; In benzene;
DOI:10.1021/jo00109a006