6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

Base Information

Chemical Name:6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride
CAS No.:1609575-46-3
Molecular Formula:C₂₃H₂₁ClF₆N₂O*ClH
Molecular Weight:527.337
Hs Code.:

Synonyms:6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

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Chemical Property of 6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

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Technology Process of 6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

There total 4 articles about 6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1602924-01-5
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid

: 28443-50-7
2-amino-5-chlorophenol

: 1609575-46-3
6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

Guidance literature:: 4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid; 2-amino-5-chlorophenol; With toluene-4-sulfonic acid; In toluene; at 135 ℃; for 2h; Sealed tube; Microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; diethyl ether; hexane;

Reference yield:

: 328-62-1
4,4,4-trifluoro-3-(nitromethyl)butyric acid ethyl ester

: 1609575-46-3
6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran; water / 0.33 h / 0 °C

1.2: 0.5 h

2.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 0 - 20 °C

3.1: sodium hydroxide; ethanol / 0.5 h / 90 °C

4.1: toluene-4-sulfonic acid / toluene / 2 h / 135 °C / Sealed tube; Microwave irradiation

With ethanol; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; acetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 1602924-00-4
4,4,4-trifluoro-3-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-butyric acid ethyl ester

: 1609575-46-3
6-chloro-2-{3,3,3-trifluoro-2-[3-(3-trifluoromethyl-phenyl)-piperidin-1-ylmethyl]-propyl}benzooxazole hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; ethanol / 0.5 h / 90 °C

2: toluene-4-sulfonic acid / toluene / 2 h / 135 °C / Sealed tube; Microwave irradiation

With ethanol; toluene-4-sulfonic acid; sodium hydroxide; In toluene;