(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

Base Information

Chemical Name:(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine
CAS No.:939398-43-3
Molecular Formula:C₂₂H₁₇F₆NO
Molecular Weight:425.373
Hs Code.:

Synonyms:(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

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Technology Process of (1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

There total 6 articles about (1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 939390-25-7
(R)-N-[(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethyl]-2-methylpropane-2-sulfinamide

: 939398-43-3
(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; at 20 ℃; for 0.166667h;

Reference yield:

: 433939-27-6
3-bromo-5-fluorophenol

: 939398-43-3
(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / dimethyl sulfoxide / 5 h / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 48 h / Inert atmosphere; Reflux

4.1: boron trifluoride diethyl etherate / diethyl ether; dichloromethane / 0.17 h / -78 °C / Inert atmosphere

4.2: 1.5 h / -78 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; n-butyllithium; boron trifluoride diethyl etherate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.5b01363

Reference yield:

: 939398-40-0
(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

: 939398-43-3
(1R)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylethan-1-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / diethyl ether; dichloromethane / 0.17 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: hydrogenchloride / methanol; 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere

With hydrogenchloride; boron trifluoride diethyl etherate; In 1,4-dioxane; methanol; diethyl ether; dichloromethane;
DOI:10.1021/acs.jmedchem.5b01363