(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide
CAS No.:939398-40-0
Molecular Formula:C₁₉H₁₇F₆NO₂S
Molecular Weight:437.406
Hs Code.:

Synonyms:(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

There total 4 articles about (R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 939398-39-7
(3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl)(4-fluorophenyl)methanone

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 939398-40-0
(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; at 20 ℃; for 48h; Heating / reflux;

Reference yield:

: 433939-27-6
3-bromo-5-fluorophenol

: 939398-40-0
(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / dimethyl sulfoxide / 5 h / 50 °C / Inert atmosphere

1.2: 1 h / 50 °C / Inert atmosphere

2.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 48 h / Inert atmosphere; Reflux

With titanium(IV) tetraethanolate; n-butyllithium; caesium carbonate; In tetrahydrofuran; diethyl ether; hexane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.5b01363

Reference yield:

: 1-bromo-3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)benzene

: 939398-40-0
(R)-N-[-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-(4-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 48 h / Inert atmosphere; Reflux

With titanium(IV) tetraethanolate; n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/acs.jmedchem.5b01363