4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

Base Information

Chemical Name:4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide
CAS No.:1451042-83-3
Molecular Formula:C₂₃H₁₉F₃N₆O₂
Molecular Weight:468.438
Hs Code.:

Synonyms:4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

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Chemical Property of 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

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Technology Process of 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

There total 2 articles about 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 641571-11-1
3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

: 1451042-82-2
methyl 3-(4-oxopyrimidin-2-ylamino)-4-methylbenzoate

: 1451042-83-3
4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -5 - 20 ℃; for 16h; Inert atmosphere;

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1451042-83-3
4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 1.5 h / 130 - 160 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 16 h / -5 - 20 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water;

Reference yield: 65.0%

: 1451042-83-3
4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide

: 1692-25-7
3-pyridylboronic acid

: 641571-10-0
nilotinib

Guidance literature:: 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-(6-oxo-1,6-dihydropyrimidin-2-ylamino)benzamide; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; at 50 ℃; for 3.5h; Inert atmosphere;

3-pyridylboronic acid; With palladium diacetate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With sodium carbonate; In tetrahydrofuran; water; for 22h; Inert atmosphere; Reflux;