(R)-tert-butyl 2-vinylpiperidine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-vinylpiperidine-1-carboxylate
CAS No.:220384-49-6
Molecular Formula:C₁₂H₂₁NO₂
Molecular Weight:211.304
Hs Code.:
DSSTox Substance ID:DTXSID301201745
Nikkaji Number:J1.068.076J

Synonyms:220384-49-6;SCHEMBL17770867;RZTACBWUQPTZHE-JTQLQIEISA-N;DTXSID301201745;(R)-tert-butyl 2-vinylpiperidine-1-carboxylate;(2R)-1-(tert-Butoxycarbonyl)-2beta-vinylpiperidine;1,1-Dimethylethyl (2R)-2-ethenyl-1-piperidinecarboxylate

Suppliers and Price of (R)-tert-butyl 2-vinylpiperidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 2-vinylpiperidine-1-carboxylate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:211.157228913
Heavy Atom Count:15
Complexity:243

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCCCC1C=C
Isomeric SMILES:CC(C)(C)OC(=O)N1CCCC[C@@H]1C=C

Technology Process of (R)-tert-butyl 2-vinylpiperidine-1-carboxylate

There total 17 articles about (R)-tert-butyl 2-vinylpiperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 134526-69-5,132910-78-2
tert-butoxycarbonyl-D-piperidine-2-carboxaldehyde

: 220384-49-6,176324-61-1
(2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

tert-butoxycarbonyl-D-piperidine-2-carboxaldehyde; In tetrahydrofuran; at -78 - 0 ℃; for 1h;

Reference yield:

: 893429-73-7
tert-butyl (R)-2-[2-(2-nitrophenylselenyl)ethyl]piperidine-1-carboxylate

: 220384-49-6,176324-61-1
(2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In phosphate buffer; dichloromethane; at 0 ℃; for 0.5h; pH=8;
DOI:10.1271/bbb.69.1589

Reference yield:

: 893430-03-0
(R)-5-azido-7-(tert-butyldiphenylsilyloxy)heptanal

: 220384-49-6,176324-61-1
(2R)-2-vinylpiperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: NaClO₂; 2-methyl-2-butene; NaH₂PO₄*2H₂O / H₂O; 2-methyl-propan-2-ol / 1 h / cooling

2: H₂ / Pd(OH)2/C / ethanol / 4 h / 20 °C

3: toluene / 1 h / Heating

4: DIBAL-H / CH₂Cl₂; toluene / 1 h / 0 °C

5: aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

6: (n-Bu)4NF / tetrahydrofuran / 8 h / 0 °C

7: (n-Bu)3P / tetrahydrofuran / 12 h / 20 °C

8: m-chloroperbenzoic acid / CH₂Cl₂; aq. phosphate buffer / 0.5 h / 0 °C / pH 8

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; phosphate buffer; ethanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1271/bbb.69.1589