5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Base Information

Chemical Name:5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile
CAS No.:1332392-79-6
Molecular Formula:C₁₉H₁₄F₃N₅O₂S
Molecular Weight:433.414
Hs Code.:

Synonyms:5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

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Chemical Property of 5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

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Technology Process of 5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

There total 5 articles about 5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 573762-62-6
5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile

: 463-71-8
thiophosgene

: 177492-52-3
MFCD 03791187

: 1332392-79-6
5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Guidance literature:: 5-amino-3-(trifluoromethyl)pyridine-2-carbonitrile; thiophosgene; MFCD 03791187; In N,N-dimethyl acetamide; at 60 ℃; for 18h;

With hydrogenchloride; water; In methanol; N,N-dimethyl acetamide; at 90 ℃; for 2h;

Reference yield:

: 887707-23-5
2-hydroxy-3-trifluoromethyl-5-(iodo)pyridine

: 1332392-79-6
5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 4 h / 110 °C

2.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / Reflux; Inert atmosphere

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 170 °C / Reflux; Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.1: N,N-dimethyl acetamide / 18 h / 60 °C

5.2: 2 h / 90 °C

With trifluoroacetic acid; sodium t-butanolate; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 887707-25-7
2-chloro-5-iodo-3-(trifluoromethyl)pyridine

: 1332392-79-6
5-(5-(4-amino-3-hydroxyphenyl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-7-yl)-3-(trifluoromethyl)picolinonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 2 h / Reflux; Inert atmosphere

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 170 °C / Reflux; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: N,N-dimethyl acetamide / 18 h / 60 °C

4.2: 2 h / 90 °C

With trifluoroacetic acid; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;