2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone

Base Information

Chemical Name:2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone
CAS No.:33284-17-2
Molecular Formula:C7H4F3NO
Molecular Weight:175.11
Hs Code.:2933399090
European Community (EC) Number:800-638-7
DSSTox Substance ID:DTXSID30603285
Nikkaji Number:J1.236.289G
Wikidata:Q72510777
Mol file:33284-17-2.mol

Synonyms:33284-17-2;2,2,2-trifluoro-1-(pyridin-2-yl)ethanone;2-(TRIFLUOROACETYL)PYRIDINE;2-(Trifluoroacetyl)pyridine (contains gem-diol);2,2,2-trifluoro-1-pyridin-2-ylethanone;Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI);2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-one;MFCD07380748;2-(Trifluoroacetyl)pyridine(containsgem-diol);2-pyridyl trifluoromethyl ketone;SCHEMBL10750254;DTXSID30603285;WBDGOEPVBPCRLY-UHFFFAOYSA-N;AKOS006285360;AB41892;CS-11095;SY005305;2,2,2-Trifluoro-1-pyridin-2-yl-ethanone;DB-068795;A5941;CS-0207621;EN300-102746

Suppliers and Price of 2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
2-(Trifluoroacetyl)pyridine(containsgem-diol) 95
10g
$ 1283.00

Crysdot
2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone 95+%
10g
$ 456.00

Chemenu
2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone 95%
10g
$ 427.00

Apolloscientific
2-(Trifluoroacetyl)pyridine 96%
1g
$ 130.00

Apolloscientific
2-(Trifluoroacetyl)pyridine 96%
5g
$ 365.00

Apolloscientific
2-(Trifluoroacetyl)pyridine 96%
10g
$ 595.00

American Custom Chemicals Corporation
2-(TRIFLUOROACETYL)PYRIDINE 95.00%
5MG
$ 505.62

Alichem
2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone
5g
$ 318.60

Alichem
2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone
10g
$ 469.68

Alichem
2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone
25g
$ 1021.68

Total 38 raw suppliers

Chemical Property of 2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone

Chemical Property:

Vapor Pressure:1.3mmHg at 25°C
Refractive Index:1.446
Boiling Point:172.9 °C at 760 mmHg
PKA:0.95±0.10(Predicted)
Flash Point:58.4 °C
PSA：29.96000
Density:1.341 g/cm³
LogP:1.82660
Storage Temp.:2-8°C
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:175.02449824
Heavy Atom Count:12
Complexity:178

Purity/Quality:

97% ^*data from raw suppliers

2-(Trifluoroacetyl)pyridine(containsgem-diol) 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(=O)C(F)(F)F

Technology Process of 2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone

There total 4 articles about 2,2,2-Trifluoro-1-(pyridin-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 107040-75-5,17556-46-6
2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-ol

: 33284-17-2
2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-one

Guidance literature:: With 2,6-dimethylpyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In dichloromethane; at 20 ℃; Sealed tube;
DOI:10.1021/jo301477s

Reference yield:

: 107040-75-5,17556-46-6
2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-ol

: 33284-17-2
2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-one

: 33284-18-3
2,2,2-trifluoro-1-(pyridine-2-yl)ethane-1,1-diol

Guidance literature:: With 9-azabicyclo[3.3.1]nonan-3-one N-oxyl oxide; oxygen; acetic acid; sodium nitrite; at 20 ℃; for 18h; under 760.051 Torr; Overall yield = 58 %; chemoselective reaction;
DOI:10.1002/adsc.201500131

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 33284-17-2
2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere; Sealed tube

1.2: 0 - 20 °C / Inert atmosphere; Sealed tube

1.3: 0 - 20 °C / Inert atmosphere; Sealed tube

2.1: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; 2,6-dimethylpyridine / dichloromethane / 20 °C / Sealed tube

With 2,6-dimethylpyridine; 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo301477s