(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Name:(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1607486-22-5
Molecular Formula:C₃₁H₃₃FN₄O₆S
Molecular Weight:608.691
Hs Code.:

Synonyms:(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Chemical Property of (R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Technology Process of (R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 9 articles about (R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607486-21-4
(R)-N-(6-fluoropyridin-2-yl)-3-(1-(2-iodophenyl)ethyl)-5-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1607486-22-5
(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate; In N,N-dimethyl acetamide; at 75 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1227465-58-8
5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride

: 1607486-22-5
(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 20 °C

2.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 °C

3.1: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / N,N-dimethyl acetamide / 3 h / 75 °C / Microwave irradiation

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; hexane; N,N-dimethyl acetamide;

Reference yield:

: 1607486-20-3
N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

: 1607486-22-5
(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 °C

2: chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate / N,N-dimethyl acetamide / 3 h / 75 °C / Microwave irradiation

With chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); caesium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl acetamide;