5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride(SALTDATA: FREE)

Base Information

• Chemical Name: 5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride(SALTDATA: FREE)
• CAS No.: 1227465-58-8
• Molecular Formula: C₈H₆ClNO₄S
• Molecular Weight: 247.659
• Mol file: 1227465-58-8.mol

Synonyms:5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride

Chemical Property of 5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride(SALTDATA: FREE)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

5-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride(SALTDATA: FREE)

There total 1 articles about 5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methylbenzo[d]oxazol-2(3H)-one (22876-15-9) → 5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride (1227465-58-8)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; at 20 ℃;

Reference yield:

5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride (1227465-58-8) + N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine (1275088-21-5) → N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide (1607486-20-3)

Guidance literature:

N-(2,4-dimethoxybenzyl)-6-fluoropyridin-2-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonyl chloride (1227465-58-8) → (R)-N-(6-fluoropyridin-2-yl)-3-(1-(2-iodophenyl)ethyl)-5-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide (1607486-21-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 20 °C

2.1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.5 h / 0 °C

With triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; hexane;

upstream raw materials:

5-methylbenzo[d]oxazol-2(3H)-one

Downstream raw materials:

(R)-N-(6-fluoropyridin-2-yl)-3-(1-(2-iodophenyl)ethyl)-5-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

(R)-tert-butyl 4-(2-(1-(6-(N-(6-fluoropyridin-2-yl)sulfamoyl)-5-methyl-2-oxobenzo[d]oxazol-3(2H)-yl)ethyl)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

N-(2,4-dimethoxybenzyl)-N-(6-fluoropyridin-2-yl)-5-methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-sulfonamide

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