(2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester
CAS No.:188118-13-0
Molecular Formula:C₂₃H₂₇NO₃
Molecular Weight:365.472
Hs Code.:

Synonyms:(2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

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Technology Process of (2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

There total 1 articles about (2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 55177-35-0
(E)-4-phenyl-2-butenal

: 20989-17-7
(2S)-2-phenylglycinol

: 188118-13-0
(2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With 1.) 4 A MS; Yield given. Multistep reaction; 1.) CH₂Cl₂, room temperature, 0.5 h, 2.) EtOAc, room temperature, 18 h;
DOI:10.1021/jo962277g

Reference yield: 92.0%

: 188118-13-0
(2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

: 188118-16-3
(3S,7R,8R,8aS)-7-Benzyl-8-bromo-3-phenyl-tetrahydro-oxazolo[3,2-c][1,3]oxazin-5-one

Guidance literature:: With N-Bromosuccinimide; In 1,2-dimethoxyethane; water; for 3h; Ambient temperature;
DOI:10.1021/jo962277g

Reference yield:

: 188118-13-0
(2S,4S,2'E)-4-phenyl-2-(3-phenylpropenyl)oxazolidine-3-carboxylic acid tert-butyl ester

: 144944-04-7
(2S,3S)-3--2-<(tert-butyldimethylsilyl)oxy>-4-phenylbutanal

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / NBS / 1,2-dimethoxy-ethane; H₂O / 3 h / Ambient temperature

2: 97 percent / ethanol / 3 h / Ambient temperature

3: 97 percent / NaN₃, NH₄Cl / ethanol; H₂O / 360 h / Heating

4: 70 percent / H₂ / 5percent Pd on carbon / ethyl acetate / 17 h

5: 90 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / -40 °C

6: 1.) DIBALH, 2.) SiO₂, oxalic acid / 1.) toluene, CH₂Cl₂, -78 deg C, 3 h, 2.) CH₂Cl₂, H₂O, room temperature, 20 h

With 2,6-dimethylpyridine; N-Bromosuccinimide; sodium azide; hydrogen; oxalic acid; silica gel; diisobutylaluminium hydride; ammonium chloride; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo962277g