1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

Base Information

Chemical Name:1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride
CAS No.:79832-26-1
Molecular Formula:C₂₀H₂₅NO₅*ClH
Molecular Weight:395.883
Hs Code.:

Synonyms:1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

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Chemical Property of 1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

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Technology Process of 1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

There total 5 articles about 1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79832-08-9
6-benzyloxy-1-(3-benzyloxy-4-methoxybenzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 79832-26-1
1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; water; for 3h; under 760 Torr;
DOI:10.1039/P19810002016

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 79832-26-1
1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / benzene / 1 h / 20 °C

2: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1.5 h

3: 1.) phorphorus oxychloride / 1.) toluene, reflux, 45 min, 2.) 20 deg C, 18 h

4: sodium borohydride / ethanol / 1.5 h / 0 °C

5: hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / ethanol; H₂O / 3 h / 760 Torr

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; hydrogen; sodium hydrogencarbonate; N,N-dimethyl-formamide; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; water; benzene;
DOI:10.1039/P19810002016

Reference yield:

: 54313-33-6
2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride

: 79832-26-1
1-(3-Hydroxy-4-methoxy-benzyl)-7,8-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-6-ol; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogen carbonate / CH₂Cl₂; H₂O / 1.5 h

2: 1.) phorphorus oxychloride / 1.) toluene, reflux, 45 min, 2.) 20 deg C, 18 h

3: sodium borohydride / ethanol / 1.5 h / 0 °C

4: hydrogen, conc. hydrochloric acid / 10percent palladium-charcoal / ethanol; H₂O / 3 h / 760 Torr

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; trichlorophosphate; palladium on activated charcoal; In ethanol; dichloromethane; water;
DOI:10.1039/P19810002016