4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

Base Information

Chemical Name:4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide
CAS No.:1602747-77-2
Molecular Formula:C₂₉H₃₀Cl₂N₄O
Molecular Weight:521.489
Hs Code.:

Synonyms:4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

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Chemical Property of 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

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Technology Process of 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

There total 5 articles about 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 23159-07-1
3-(1-pyrrolidinyl)propylamine

: 1602748-79-7
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole-1-yl)methyl)benzoic acid

: 1602747-77-2
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

Guidance literature:: 4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazole-1-yl)methyl)benzoic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

3-(1-pyrrolidinyl)propylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.11.017

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 1602747-77-2
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: polyphosphoric acid / 4 h / 175 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With water; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 6575-24-2
2-(2,6-dichlorophenyl)acetic acid

: 1602747-77-2
4-((2-(2,6-dichlorobenzyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(pyrrolidin-1-yl)propyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: polyphosphoric acid / 4 h / 175 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With water; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;