(E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one

Base Information

• Chemical Name: (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one
• CAS No.: 125455-70-1
• Molecular Formula: C₂₀H₁₈O
• Molecular Weight: 274.362
• Mol file: 125455-70-1.mol

Synonyms:(E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one

Chemical Property of (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one

There total 6 articles about (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-Phenyl-2-(phenylmethyl)-2-hepten-5-yn-4-one (120696-21-1) → 3-benzyl-5-methyl-4-phenylphenol (125443-13-2) + (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one (125455-70-1)

Guidance literature:

collidine p-toluenesulfonate; Heating;

DOI:10.1016/S0040-4039(00)88463-4

Reference yield: 10.0%

1-Phenyl-2-(phenylmethyl)-2-hepten-5-yn-4-one (120696-21-1) → (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one (125455-70-1)

Guidance literature:

With sodium hydrogencarbonate; In 1,2-dichloro-ethane; at 83 ℃; for 127h;

DOI:10.1016/S0040-4039(00)88462-2

Reference yield:

4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester (157731-51-6) → (E)-5-Ethylidene-4-phenyl-3-(phenylmethyl)-2-cyclopenten-1-one (125455-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) AlMe₃ / 1.) benzene, toluene, r.t., 1 h, 2.) r.t.

2: 62 percent / Ph₃CH, n-BuLi / 1.) -78 deg C, 15 min, 2.) r.t., 3 h

3: 4-tert-butylcatechol, NaHCO₃ / various solvent(s) / 1 h / 124 °C / various solvents, time, temp.; other phenols; further enynones

With n-butyllithium; triphenylmethane; 4-tert-Butylcatechol; trimethylaluminum; sodium hydrogencarbonate; In various solvent(s);

DOI:10.1021/jo00097a035

upstream raw materials:

1-Phenyl-2-(phenylmethyl)-2-hepten-5-yn-4-one

4-Phenyl-3-(phenylmethyl)-2-butenoic acid methyl ester

N-Methoxy-N-methyl-4-phenyl-3-(phenylmethyl)-2-butenamide

1,3-Diphenylpropanone