C₂₆H₃₁N₅O₆

Base Information

• Chemical Name: C₂₆H₃₁N₅O₆
• CAS No.: 1422363-53-8
• Molecular Formula: C₂₆H₃₁N₅O₆
• Molecular Weight: 509.562
• Mol file: 1422363-53-8.mol

Synonyms:C₂₆H₃₁N₅O₆

Chemical Property of C₂₆H₃₁N₅O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₃₁N₅O₆

There total 9 articles about C₂₆H₃₁N₅O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H25NO6 (1422363-58-3) → C26H31N5O6 (1422363-53-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

3.1: phosphorus tribromide / tetrahydrofuran / 2 h / 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

4.2: 4 h / 0 °C

5.1: dichloromethane / 20 °C

6.1: triethylamine; dmap / dichloromethane / 24 h / 20 °C

With dmap; phosphorus tribromide; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c2cc38382a

Reference yield:

N-allyloxycarbonyl α-allyl-L-glutamate (91871-28-2) → C26H31N5O6 (1422363-53-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

2.1: phosphorus tribromide / tetrahydrofuran / 2 h / 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

3.2: 4 h / 0 °C

4.1: dichloromethane / 20 °C

5.1: triethylamine; dmap / dichloromethane / 24 h / 20 °C

With dmap; phosphorus tribromide; sodium hydride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;

DOI:10.1039/c2cc38382a

Reference yield:

Fmoc-Glu(OtBu)-OH (71989-18-9) → C26H31N5O6 (1422363-53-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: caesium carbonate / methanol; water / pH 7

1.2: 12 h / 0 - 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diethylamine / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.1: sodium carbonate / water; 1,4-dioxane / 1.17 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 20 °C

5.1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 20 °C / Inert atmosphere

6.1: phosphorus tribromide / tetrahydrofuran / 2 h / 0 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C / Cooling with ice

7.2: 4 h / 0 °C

8.1: dichloromethane / 20 °C

9.1: triethylamine; dmap / dichloromethane / 24 h / 20 °C

With dmap; phosphorus tribromide; sodium hydride; sodium carbonate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; diethylamine; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; mineral oil;

DOI:10.1039/c2cc38382a

upstream raw materials:

C₁₆H₂₅NO₆

N-allyloxycarbonyl α-allyl-L-glutamate

Fmoc-Glu(OtBu)-OH

allyl (S)-2-((allyloxycarbonyl)amino)-5-((4-(hydroxymethyl)phenyl)amino)-5-oxopentanoate

Downstream raw materials:

C₁₉H₂₃N₅O₄