[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

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Chemical Name:[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester
CAS No.:161167-55-1
Molecular Formula:C₂₃H₄₄O₄Si₂
Molecular Weight:440.771
Hs Code.:

Synonyms:[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

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Chemical Property of [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

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Technology Process of [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

There total 8 articles about [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 127492-03-9
1-(phenylsulfinyl)-2,2,2-triethoxyethane

: 127492-02-8
(4R-trans)-4,6-Bis(tert-butyldimethylsiloxy)-1-cyclohexenemethanol

: 161167-55-1
[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: trimethylbenzoic acid; In dichloromethane; at 100 ℃; for 12h;
DOI:10.1021/jo00300a001

Reference yield:

: 99268-87-8
3-(p-toluenesulfonyl)-2-pyrone

: 161167-55-1
[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / bis(2,6-di-tert-butyl-4-methylphenoxy)-methylaluminium / toluene; CH₂Cl₂ / 12 h / -45 °C

3: 1.) CF₃COOH, 2.) MeOH / 1.) CH₂Cl₂, 0 deg C, 9h, 2.) 25 deg C, 10h

4: imidazole / dimethylformamide / 14 h / 25 °C

5: 94 percent / diisobutylaluminum hydride / toluene / 1 h / -78 °C

6: 89 percent / trimethylbenzoic acid / CH₂Cl₂ / 12 h / 100 °C

With 1H-imidazole; methanol; diisobutylaluminium hydride; trifluoroacetic acid; bis(2,6-di-tert-butyl-4-methylphenoxy)-methylaluminium; trimethylbenzoic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00300a001

Reference yield:

: 127492-01-7
chiron

: 161167-55-1
[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / diisobutylaluminum hydride / toluene / 1 h / -78 °C

2: 89 percent / trimethylbenzoic acid / CH₂Cl₂ / 12 h / 100 °C

With diisobutylaluminium hydride; trimethylbenzoic acid; In dichloromethane; toluene;
DOI:10.1021/jo00300a001