127492-01-7

Basic information

• Product Name: chiron
• Synonyms: chiron
• CAS NO: 127492-01-7
• Molecular Weight: 400.706
• Mol File: 127492-01-7.mol

Chemical Properties

• CAS DataBase Reference: chiron(CAS DataBase Reference)
• NIST Chemistry Reference: chiron(127492-01-7)
• EPA Substance Registry System: chiron(127492-01-7)

Safety Data

• Hazardous Substances Data: 127492-01-7(Hazardous Substances Data)

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 104464-04-2 (1S,4R,8S)-8-((S)-2-Methyl-1-phenyl-propoxy)-4-(toluene-4-sulfonyl)-2-oxa-bicyclo[2.2.2]oct-5-en-3-one 
• 104487-42-5 (4R,6S)-4-Hydroxy-6-((S)-2-methyl-1-phenyl-propoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 99268-87-8 3-(p-toluenesulfonyl)-2-pyrone 
• 145364-55-2 2-Oxo-2H-pyran-3-carboxylic acid (S)-1-methoxycarbonyl-ethyl ester 
• 3040-20-8 2-pyrone-3-carboxylic acid 
• 18398-80-6 2-pyrone-3-carboxylic acid chloride 
• 173914-18-6 (1S,4S,6S)-4-Hydroxy-6-(naphthalen-1-ylmethoxy)-cyclohex-2-ene-1,1-dicarboxylic acid allyl ester methyl ester 
• 173914-19-7 (1S,4S,6S)-6-(tert-Butyl-dimethyl-silanyloxy)-4-hydroxy-cyclohex-2-ene-1,1-dicarboxylic acid allyl ester methyl ester 
• 162273-00-9 (1S,4S,8S)-8-(Naphthalen-1-ylmethoxy)-3-oxo-2-oxa-bicyclo[2.2.2]oct-5-ene-4-carboxylic acid methyl ester 
• 162273-01-0 (1S,4S,8S)-8-(tert-Butyl-dimethyl-silanyloxy)-3-oxo-2-oxa-bicyclo[2.2.2]oct-5-ene-4-carboxylic acid methyl ester 
• 66031-93-4 tert-butyldimethylsilyl vinyl ether 
• 162273-02-1 (4R,6S)-4-Hydroxy-6-(naphthalen-1-ylmethoxy)-cyclohex-1-enecarboxylic acid methyl ester 
• 25991-27-9 methyl 2-oxo-2H-pyrane-3-carboxylate 

Downstream Products

• 161167-55-1 [(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-acetic acid ethyl ester 
• 127491-99-0 (1RS,3S,5R)-3,5-bis(t-butyldimethylsiloxy)-1-carboethoxymethyl-2-methylenecyclohexane 
• 127492-02-8 (4R-trans)-4,6-Bis(tert-butyldimethylsiloxy)-1-cyclohexenemethanol 

Relevant articles and documents

Lewis acid-promoted, stereocontroiled, gram scale, diels-alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: The critical importance of molecular sieves and the temperature of titanium coordination with the pyrone

(R)-(+)-Binol-titanium coordinates with commercial methyl 2-pyrone-3-carboxylate and promotes mild, highly enantiocontrolled Diels-Alder cycloadditions with electron-rich vinyl ether CH2=CHOCH2-1-naphthyl and vinyl silyl ether CHsub

Binaphthol-titanium-promoted, highly enantiocontrolled, Diels-Alder cycloadditions of electronically matched 2-pyrones and vinyl ethers: Streamlined asymmetric synthesis of an A-ring precursor to physiologically active 1α-hydroxyvitamin D3 ster

Bicyclic lactones 4, A-ring precursors to diverse physiologically active 1α-hydroxyvitamin D3 analogs, were prepared in excellent yields and enantiomeric purities via chiral, non-racemic Lewis acid-promoted, mild, inverse-electron-demand 4+2-cy

A New and Efficient Asymmetric Synthesis of an A-Ring Precursor to Physiologically Active 1α-Hydroxyvitamin D3 Steroids

A highly stereocontrolled and mild Diels-Alder cycloaddition involving stereochemically matched pyrone (S)-lactate 4 and Lewis acid (-)-Pr(hfc)3 produced bicyclic lactone endo-5 via a double stereodifferentiation process.Bicyclic lactone 5 was then transf

Asymmetric total synthesis of an a-ring precursor to hormonally active 1α,25-dihydroxyvitamin D3

A new sulfinyl orthoester has been designed and used effectively in one-flask syntheses of dienoate esters from allylic alcohols; this new method as well as a highly stereocontrolled [2 + 4]-cycloaddition are applied to synthesis of 1α,25-dihydroxyvitamin D3.