N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

Base Information

Chemical Name:N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide
CAS No.:177499-56-8
Molecular Formula:C₂₂H₂₁N₃O
Molecular Weight:343.428
Hs Code.:

Synonyms:N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

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Technology Process of N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

There total 1 articles about N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 98-88-4
benzoyl chloride

: 2-Amino-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrole-3-carbonitrile

: 177499-56-8
N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

Guidance literature:: With pyridine; In dichloromethane; for 1h;
DOI:10.1021/jm960011w

Reference yield: 51.0%

: 177499-56-8
N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

: 177499-47-7
5,6-Dimethyl-2-phenyl-7-((R)-1-phenyl-ethyl)-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one

Guidance literature:: With N,N-dimethyl-cyclohexanamine; water; phosphorus pentoxide; at 190 - 200 ℃; for 4h;
DOI:10.1021/jm960011w

Reference yield:

: 177499-56-8
N-[3-Cyano-4,5-dimethyl-1-((R)-1-phenyl-ethyl)-1H-pyrrol-2-yl]-benzamide

: (R,R)-5,6-dimethyl-7-(1-methylbenzyl)-2-phenyl-7H-pyrrolo[2,3-d]pyrimidine-4-(1-methylbenzyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: aq. P₂O₅; N,N-dimethylcyclohexylamine / 4 h / 190 - 200 °C

2: POCl₃ / 1 h / Heating

3: 77 percent / ethanol / 70 h / Heating

With N,N-dimethyl-cyclohexanamine; phosphorus pentoxide; trichlorophosphate; In ethanol;
DOI:10.1021/jm000967d