6H-thiazolo[5,4-e]indol-7(8H)-one

Base Information

Chemical Name:6H-thiazolo[5,4-e]indol-7(8H)-one
CAS No.:222036-27-3
Molecular Formula:C₉H₆N₂OS
Molecular Weight:190.225
Hs Code.:2934999090
DSSTox Substance ID:DTXSID60455774
Wikidata:Q82277908
Mol file:222036-27-3.mol

Synonyms:6H-thiazolo[5,4-e]indol-7(8H)-one;222036-27-3;6,8-dihydropyrrolo[2,3-g][1,3]benzothiazol-7-one;6,8-Dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one;6.8-dihydro-1-thia-3,6-diaza-as-indacen-7-one;SCHEMBL5873762;DTXSID60455774;IMPZLDDOQIAFJH-UHFFFAOYSA-N;AKOS015856631;F51303;6,8-dihydro-1-thia-3,6-diaza-as-indacen-7-one;6,8-dihydro-l-thia-3,6-diaza-as-indacen-7-one;A898373;7h-pyrrolo[2,3-g]benzothiazol-7-one,6,8-dihydro-

Suppliers and Price of 6H-thiazolo[5,4-e]indol-7(8H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one
50mg
$ 245.00

Crysdot
6H-Thiazolo[5,4-e]indol-7(8H)-one 95+%
1g
$ 935.00

Total 6 raw suppliers

Chemical Property of 6H-thiazolo[5,4-e]indol-7(8H)-one

Chemical Property:

PSA：73.72000
LogP:1.87600
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated)
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:190.02008399
Heavy Atom Count:13
Complexity:246

Purity/Quality:

97% ^*data from raw suppliers

6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=C(C=CC3=C2SC=N3)NC1=O
Uses 6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one is an intermediate in synthesizing Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). It is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.

Technology Process of 6H-thiazolo[5,4-e]indol-7(8H)-one

There total 3 articles about 6H-thiazolo[5,4-e]indol-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 222036-26-2
8-(methylsulfanyl)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

: 222036-27-3
6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

Guidance literature:: With acetic acid; zinc; In tetrahydrofuran; at 60 ℃; for 2.5h; Heating / reflux;

Reference yield:

: 533-30-2
1,3-benzothiazol-6-amine

: 4455-13-4
methylthioacetic acid ethyl ester

: 222036-27-3
6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

Guidance literature:: With hydrogenchloride; nitrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 533-30-2
1,3-benzothiazol-6-amine

: 222036-27-3
6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / Zn; acetic acid / tetrahydrofuran / 3.5 h / 60 - 65 °C

With acetic acid; zinc; In tetrahydrofuran;
DOI:10.1021/jm010117d