222036-26-2

Usage

Uses

Used in Pharmaceutical Industry:
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is used as an intermediate in the synthesis of PKR inhibitors for their potential therapeutic applications. As a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR), it has demonstrated effective inhibition of PKR function in vivo. This inhibition can lead to various beneficial effects, such as neuroprotection and cognitive enhancement, as observed in animal studies.
Used in Neuroprotective Applications:
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is used as a neuroprotective agent due to its role in the synthesis of PKR inhibitors. These inhibitors have shown to provide protection against neuronal damage and degeneration, which can be particularly useful in the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis.
Used in Nootropic Applications:
8-METHYLSULFANYL-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE is used as a nootropic agent, contributing to the development of PKR inhibitors with cognitive-enhancing properties. These inhibitors can potentially improve memory, learning, and overall cognitive function, making them valuable in the treatment of cognitive disorders and for enhancing cognitive performance in healthy individuals.

InChI:InChI=1/C10H8N2OS2/c1-14-9-7-5(12-10(9)13)2-3-6-8(7)15-4-11-6/h2-4,9H,1H3,(H,12,13)

Upstream product

• 533-30-2 1,3-benzothiazol-6-amine 
• 4455-13-4 methylthioacetic acid ethyl ester 

Downstream Products

• 222036-27-3 6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one 
• 222036-17-1 4-{[(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-N-(2-pyridinyl)benzenesulfonamide 

Relevant academic research and scientific papers

3-(anilinomethylene) oxindoles

The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of

Thiazoloindolinone compounds

Thiazole-indole compounds useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiation therapy in a patient receiving such therapy.

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis

Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently inhibit cyclin-dependent kinase 2 (CDK2). The initial lead compound was prepared as a homologue of the 3-benzylidene-1,3-dihydro-2H-indol-2-one class of kinase inhibitor. Crystallographic analysis of the lead compound bound to CDK2 provided the basis for analogue design. A semiautomated method of ligand docking was used to select compounds for synthesis, and a number of compounds with low nanomolar inhibitory activity versus CDK2 were identified. Enzyme binding determinants for several analogues were evaluated by X-ray crystallography. Compounds in this series inhibited CDK2 with a potency ～10-fold greater than that for CDK1. Members of this class of inhibitor cause an arrest of the cell cycle and have shown potential utility in the prevention of chemotherapy-induced alopecia.