tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

Base Information

Chemical Name:tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate
CAS No.:842166-62-5
Molecular Formula:C₃₇H₅₃N₅O₆S
Molecular Weight:695.924
Hs Code.:

tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

Synonyms:tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

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Chemical Property of tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

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Technology Process of tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

There total 4 articles about tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199588-96-0
tert-butyl (S)-2-amino-3-(2-naphthyl)propanoate

: Boc-Arg(Mts)-H

: 842166-62-5
tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

Guidance literature:: tert-butyl (S)-2-amino-3-(2-naphthyl)propanoate; Boc-Arg(Mts)-H; With acetic acid; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 4 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1021/jm049429h

Reference yield:

: 68262-71-5,200122-85-6
Boc-Arg(MTS)-OH

: 842166-62-5
tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / potassium bicarbonate / dimethylformamide / 10 h / 20 °C

2.1: DIBAL-H / toluene; CH₂Cl₂ / 2 h / -78 °C

3.1: AcOH / 1,2-dichloro-ethane; dimethylformamide / 0.17 h / 4 °C

3.2: 3.4 g / NaBH(OAc)3 / 1,2-dichloro-ethane; dimethylformamide / 8 h / 20 °C

With diisobutylaluminium hydride; potassium hydrogencarbonate; acetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm049429h

Reference yield:

: Boc-Arg(Mts)-NMe(OMe)

: 842166-62-5
tert-butyl (2S)-[[(2S)-[(tert-butoxy)carbonylamino]-5-[[imino[[(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]amino]pentyl]amino]-3-(2-naphthyl) propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: DIBAL-H / toluene; CH₂Cl₂ / 4 h / -78 °C

2.1: AcOH / 1,2-dichloro-ethane; dimethylformamide / 0.17 h / 4 °C

2.2: 3.4 g / NaBH(OAc)3 / 1,2-dichloro-ethane; dimethylformamide / 8 h / 20 °C

With diisobutylaluminium hydride; acetic acid; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm049429h