3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI)

Base Information

Chemical Name:3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI)
CAS No.:221876-51-3
Molecular Formula:C₉H₂₀N₂O
Molecular Weight:172.271
Hs Code.:
Mol file:221876-51-3.mol

Synonyms:3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI)

Suppliers and Price of 3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI)

Chemical Property:

PSA：0.00000
LogP:0.00000

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI)

There total 3 articles about 3-Pyrrolidinemethanol,4-(methylamino)-5-(1-methylethyl)-,(3R,4R,5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 221876-48-8
(1R,5R,8S)-(+)-7-Benzyl-8-isopropyl-2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octan

: 221876-51-3
(2S,3R,4R)-(2-Isopropyl-3-methylaminopyrrolidin-4-yl)methanol

Guidance literature:: With hydrogen; acetic acid; palladium dihydroxide; In ethanol; at 60 ℃; for 24h; under 75006 Torr;
DOI:10.1515/znb-1999-0117

Reference yield:

: (S)-2-(N-allyl-benzylamino)-3-methylbutanal

: 221876-51-3
(2S,3R,4R)-(2-Isopropyl-3-methylaminopyrrolidin-4-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / H₂O / 3 h / 20 °C

2: H₂; MeCOOH / 20 percent Pd(OH)2/C / ethanol / 24 h / 60 °C / 75006 Torr

With hydrogen; magnesium sulfate; acetic acid; palladium dihydroxide; In ethanol; water; 1: Cyclization / 2: Ring cleavage;
DOI:10.1515/znb-1999-0117

Reference yield:

: 148759-64-2
(S)-(+)-2-Allyl(benzyl)amino-3-methyl-1-butanol

: 221876-51-3
(2S,3R,4R)-(2-Isopropyl-3-methylaminopyrrolidin-4-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 °C

2: MgSO₄ / H₂O / 3 h / 20 °C

3: H₂; MeCOOH / 20 percent Pd(OH)2/C / ethanol / 24 h / 60 °C / 75006 Torr

With oxalyl dichloride; hydrogen; magnesium sulfate; acetic acid; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In ethanol; dichloromethane; water; 1: Oxidation / 2: Cyclization / 3: Ring cleavage;
DOI:10.1515/znb-1999-0117