dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate

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Chemical Name:dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate
CAS No.:1332360-48-1
Molecular Formula:C₃₃H₃₅N₃O₁₀S
Molecular Weight:665.721
Hs Code.:

Synonyms:dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate

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Chemical Property of dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate

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Technology Process of dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate

There total 2 articles about dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1332360-36-7
C₁₁H₁₁NO₆S

: 66025-58-9
L-alanyl-D-glutamic acid dibenzyl ester trifluoroacetate

: 1332360-48-1
dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In acetonitrile; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2011.05.042

Reference yield:

: 59524-70-8,59524-71-9,85546-28-7
dibenzyl N-[N-(tert-butoxycarbonyl)-L-alanyl]-D-glutamate

: 1332360-48-1
dibenzyl (2R)-2-{[(2S)-2-({2-[2-(1,1,3-trioxo-1,3-dihydro-2H-1,2-benzisothiazol-2-yl)ethoxy]acetyl}amino)propanoyl]amino}pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 3 h / 0 - 20 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / acetonitrile / 3 h / 0 - 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2011.05.042